Ontology highlight
ABSTRACT:
SUBMITTER: Pavlopoulos GA
PROVIDER: S-EPMC10584684 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Pavlopoulos Georgios A GA Baltoumas Fotis A FA Liu Sirui S Selvitopi Oguz O Camargo Antonio Pedro AP Nayfach Stephen S Azad Ariful A Roux Simon S Call Lee L Ivanova Natalia N NN Chen I Min IM Paez-Espino David D Karatzas Evangelos E Iliopoulos Ioannis I Konstantinidis Konstantinos K Tiedje James M JM Pett-Ridge Jennifer J Baker David D Visel Axel A Ouzounis Christos A CA Ovchinnikov Sergey S Buluç Aydin A Kyrpides Nikos C NC
Nature 20231011 7983
Metagenomes encode an enormous diversity of proteins, reflecting a multiplicity of functions and activities<sup>1,2</sup>. Exploration of this vast sequence space has been limited to a comparative analysis against reference microbial genomes and protein families derived from those genomes. Here, to examine the scale of yet untapped functional diversity beyond what is currently possible through the lens of reference genomes, we develop a computational approach to generate reference-free protein f ...[more]