Complete human day 14 post-implantation embryo models from naive ES cells.

ABSTRACT: The ability to study human post-implantation development remains limited owing to ethical and technical challenges associated with intrauterine development after implantation¹. Embryo-like models with spatially organized morphogenesis and structure of all defining embryonic and extra-embryonic tissues of the post-implantation human conceptus (that is, the embryonic disc, the bilaminar disc, the yolk sac, the chorionic sac and the surrounding trophoblast layer) remain lacking^1,2. Mouse naive embryonic stem cells have recently been shown to give rise to embryonic and extra-embryonic stem cells capable of self-assembling into post-gastrulation structured stem-cell-based embryo models with spatially organized morphogenesis (called SEMs)³. Here we extend those f

SUBMITTER: Oldak B 

PROVIDER: S-EPMC10584686 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature