Quantitative LC-MS study of compounds found predictive of COVID-19 severity and outcome.

ABSTRACT:

Introduction

Since the beginning of the SARS-CoV-2 pandemic in December 2019 multiple metabolomics studies have proposed predictive biomarkers of infection severity and outcome. Whilst some trends have emerged, the findings remain intangible and uninformative when it comes to new patients.

Objectives

In this study, we accurately quantitate a subset of compounds in patient serum that were found predictive of severity and outcome.

Methods

A targeted LC-MS method was used in 46 control and 95 acute COVID-19 patient samples to quantitate the selected metabolites. These compounds included tryptophan and its degradation products kynurenine and kynurenic acid (reflective of immune response), butyrylcarnitine and its isomer (reflective of energy metabolism) and finally 3',4'-

SUBMITTER: Roberts I 

PROVIDER: S-EPMC10584727 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature