Sodium-hyaluronate mouthwash on radiotherapy-induced xerostomia: a randomised clinical trial.

ABSTRACT:

Introduction

Radiotherapy-induced xerostomia (RIX) is one of the most common adverse effects of radiotherapy (RT) in head and neck cancer patients (HNC) and a major determinant of survivors' quality of life. The primary objective was to evaluate the reduction of patients' xerostomia symptoms after the utilisation of a sodium-hyaluronate mouthwash compared to a placebo solution. The secondary objectives were to evaluate the improvement of quality of life and to evaluate the patients' satisfaction.

Methods

The protocol was approved by the ethical committee (Ref. 50,053/19) and registered at ClinicalTrials.gov (ID: NCT05103124). The study was a double-blind randomised clinical trial (RCT) with a crossover design and was conducted at the Fondazione Policlinico Universitario A. G

SUBMITTER: Rupe C 

PROVIDER: S-EPMC10584731 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature