Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study.

ABSTRACT:

Background

Prophylactic high-flow nasal cannula (HFNC) oxygen therapy can decrease the risk of extubation failure. It is frequently used in the postextubation phase alone or in combination with noninvasive ventilation. However, its physiological effects in this setting have not been thoroughly investigated. The aim of this study was to determine comprehensively the effects of HFNC applied after extubation on respiratory effort, diaphragm activity, gas exchange, ventilation distribution, and cardiovascular biomarkers.

Methods

This was a prospective randomized crossover physiological study in critically ill patients comparing 1 h of HFNC versus 1 h of standard oxygen after extubation. The main inclusion criteria were mechanical ventilation for at least 48 h due to acute respir

SUBMITTER: Basoalto R 

PROVIDER: S-EPMC10584771 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature