Quantitative ¹⁷⁷Lu SPECT/CT imaging for personalized dosimetry using a ring-shaped CZT-based camera.

ABSTRACT:

Background

Dosimetry after radiopharmaceutical therapy with ¹⁷⁷Lu (¹⁷⁷Lu-RPT) relies on quantitative SPECT/CT imaging, for which suitable reconstruction protocols are required. In this study, we characterized for the first time the quantitative performance of a ring-shaped CZT-based camera using two different reconstruction algorithms: an ordered subset expectation maximization (OSEM) and a block sequential regularized expectation maximization (BSREM) combined with noise reduction regularization. This study lays the foundations for the definition of a reconstruction protocol enabling accurate dosimetry for patients treated with ¹⁷⁷Lu-RPT.

Methods

A series of ¹⁷⁷Lu-filled phantoms were acquired on a StarGuide™ (GE HealthCare), with

SUBMITTER: Danieli R 

PROVIDER: S-EPMC10584798 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature