Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants.

ABSTRACT: There is renewed interest in the use of lysergic acid diethylamide (LSD) in psychiatric research and practice. Although acute subjective effects of LSD are mostly positive, negative subjective effects, including anxiety, may occur. The induction of overall positive acute subjective effects is desired in psychedelic-assisted therapy because positive acute experiences are associated with greater therapeutic long-term benefits. 3,4-Methylenedioxymethamphetamine (MDMA) produces marked positive subjective effects and is used recreationally with LSD, known as "candyflipping." The present study investigated whether the co-administration of MDMA can be used to augment acute subjective effects of LSD. We used a double-blind, randomized, placebo-controlled, crossover design with 24 healthy subjects

SUBMITTER: Straumann I 

PROVIDER: S-EPMC10584820 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature