Effect of remote ischemic preconditioning on lung function after surgery under general anesthesia: a systematic review and meta-analysis.

ABSTRACT: Remote ischemic preconditioning (RIPC) protects organs from ischemia-reperfusion injury. Recent trials showed that RIPC improved gas exchange in patients undergoing lung or cardiac surgery. We performed a systematic search to identify randomized controlled trials involving RIPC in surgery under general anesthesia. The primary outcome was the P_aO₂/F_IO₂ (P/F) ratio at 24 h after surgery. Secondary outcomes were A-a DO₂, the respiratory index, duration of postoperative mechanical ventilation (MV), incidence of acute respiratory distress syndrome (ARDS), and serum cytokine levels. The analyses included 71 trials comprising 7854 patients. Patients with RIPC showed higher P/F ratio than controls (mean difference [MD] 36.6, 95% confidence int

SUBMITTER: Kashiwagi S 

PROVIDER: S-EPMC10584824 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature