Use of transcranial low-intensity focused ultrasound for targeted delivery of stem cell-derived exosomes to the brain.

ABSTRACT: The blood-brain barrier (BBB) presents a significant challenge for targeted drug delivery. A proposed method to improve drug delivery across the BBB is focused ultrasound (fUS), which delivers ultrasound waves to a targeted location in the brain and is hypothesized to open the BBB. Furthermore, stem cell-derived exosomes have been suggested as a possible anti-inflammatory molecule that may have neural benefits, if able to pass the BBB. In the present study, transcranial low-intensity focused ultrasound (LIFU), without the use of intravenous microbubbles, was assessed for both (1) its ability to influence the BBB, as well as (2) its ability to increase the localization of intravenously administered small molecules to a specific region in the brain. In vivo rat studies were conducted with a

SUBMITTER: Haroon J 

PROVIDER: S-EPMC10584845 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature