Ontology highlight
ABSTRACT:
SUBMITTER: Vazquez-Juarez E
PROVIDER: S-EPMC10584870 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Vazquez-Juarez Erika E Srivastava Ipsit I Lindskog Maria M
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20230610 13
Mistuning of synaptic transmission has been proposed to underlie many psychiatric disorders, with decreased reuptake of the excitatory neurotransmitter glutamate as one contributing factor. Synaptic tuning occurs through several diverging and converging forms of plasticity. By recording evoked field postsynaptic potentials in the CA1 area in hippocampal slices, we found that inhibiting glutamate transporters using DL-TBOA causes retuning of synaptic transmission, resulting in a new steady state ...[more]