Designing and computational analyzing of chimeric long-lasting GLP-1 receptor agonists for type 2 diabetes.

ABSTRACT: Glucagon-like peptide-1 (GLP-1) is an intestinally derived incretin that plays a vital role in engineering the biological circuit involved in treating type 2 diabetes. Exceedingly short half-life (1-2 min) of GLP-1 limits its therapeutic applicability, and the implication of its new variants is under question. Since albumin-binding DARPin as a mimetic molecule has been reported to increase the serum half-life of therapeutic compounds, the interaction of new variants of GLP-1 in fusion with DARPin needs to be examined against the GLP-1 receptor. This study was aimed to design stable and functional fusion proteins consisting of new protease-resistant GLP-1 mutants (mGLP1) genetically fused to DARPin as a critical step toward developing long-acting GLP-1 receptor agonists. The stability and s

SUBMITTER: Ehsasatvatan M 

PROVIDER: S-EPMC10584922 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature