EEG-based biomarkers for optimizing deep brain stimulation contact configuration in Parkinson's disease.

ABSTRACT:

Objective

Subthalamic deep brain stimulation (STN-DBS) is a neurosurgical therapy to treat Parkinson's disease (PD). Optimal therapeutic outcomes are not achieved in all patients due to increased DBS technological complexity; programming time constraints; and delayed clinical response of some symptoms. To streamline the programming process, biomarkers could be used to accurately predict the most effective stimulation configuration. Therefore, we investigated if DBS-evoked potentials (EPs) combined with imaging to perform prediction analyses could predict the best contact configuration.

Methods

In 10 patients, EPs were recorded in response to stimulation at 10 Hz for 50 s on each DBS-contact. In two patients, we recorded from both hemispheres, resulting in recordings from a t

SUBMITTER: Peeters J 

PROVIDER: S-EPMC10585033 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature