Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice.

ABSTRACT:

Introduction

Influenza vaccines play a vital role in protecting individuals from influenza virus infection and severe illness. However, current influenza vaccines have suboptimal efficacy, which is further reduced in cases where the vaccine strains do not match the circulating strains. One strategy to enhance the efficacy of influenza vaccines is by extended antigen delivery, thereby mimicking the antigen kinetics of a natural infection. Prolonging antigen availability was shown to quantitatively enhance influenza virus-specific immune responses but how it affects the quality of the induced immune response is unknown. Therefore, the current study aimed to investigate whether prolongation of the delivery of influenza vaccine improves the quality of the induced immune responses over

SUBMITTER: Beukema M 

PROVIDER: S-EPMC10585035 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature