Antigen-dependent modulation of immune responses to antigen-Fc fusion proteins by Fc-effector functions.

ABSTRACT:

Background

Fc-fusion proteins have been successfully developed for therapeutic purposes, but are also a promising platform for the fast generation and purification of immunogens capable of inducing strong humoral immune responses in preclinical immunization studies. As the Fc-portion of immunoglobulins fused to an antigen confers functional properties of the parental antibody, such as dimerization, binding to Fc-receptors and complement activation, several studies reported that Fc-fusion proteins elicit stronger antigen-specific antibody responses than the unfused antigen. However, dimerization or half-life extension of an antigen have also been described to enhance immunogenicity.

Methods

To explore the role of Fc-effector functions for the immunogenicity of fusions protein

SUBMITTER: Richel E 

PROVIDER: S-EPMC10585040 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature