Susceptibility and severity of COVID-19 and risk of psychiatric disorders in European populations: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested that COVID-19 increases the prevalence of psychiatric disorders, but the results of such studies are inconsistent. This study aims to investigate the association between COVID-19 and the risk of psychiatric disorders using Mendelian randomization (MR) analysis.

Methods

We used summary statistics from COVID-19 Host Genetics Initiative genome-wide association study (GWAS) of COVID-19 involving 2,586,691 participants from European ancestry. Genetic variations of five psychiatric disorders including autism spectrum disorder (ASD) (N = 46,351), bipolar disorder (BID) (N = 51,710), major depressive disorder (MDD) (N = 480,359), anxiety disorder (N = 83,566), and schizophrenia (SCZ) (N = 77,096) were

SUBMITTER: Xue H 

PROVIDER: S-EPMC10585067 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature