Tracking cell turnover in human brain using ¹⁵N-thymidine imaging mass spectrometry.

ABSTRACT: Microcephaly is often caused by an impairment of the generation of neurons in the brain, a process referred to as neurogenesis. While most neurogenesis in mammals occurs during brain development, it thought to continue to take place through adulthood in selected regions of the mammalian brain, notably the hippocampus. However, the generality of neurogenesis in the adult brain has been controversial. While studies in mice and rats have provided compelling evidence for neurogenesis occurring in the adult rodent hippocampus, the lack of applicability in humans of key methods to demonstrate neurogenesis has led to an intense debate about the existence and, in particular, the magnitude of neurogenesis in the adult human brain. Here, we demonstrate the applicability of a powerful method to addre

SUBMITTER: Roeder SS 

PROVIDER: S-EPMC10585107 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature