A plasma miRNA-based classifier for small cell lung cancer diagnosis.

ABSTRACT:

Introduction

Small cell lung cancer (SCLC) is characterized by poor prognosis and challenging diagnosis. Screening in high-risk smokers results in a reduction in lung cancer mortality, however, screening efforts are primarily focused on non-small cell lung cancer (NSCLC). SCLC diagnosis and surveillance remain significant challenges. The aberrant expression of circulating microRNAs (miRNAs/miRs) is reported in many tumors and can provide insights into the pathogenesis of tumor development and progression. Here, we conducted a comprehensive assessment of circulating miRNAs in SCLC with a goal of developing a miRNA-based classifier to assist in SCLC diagnoses.

Methods

We profiled deregulated circulating cell-free miRNAs in the plasma of SCLC patients. We tested selected miRNAs

SUBMITTER: Saviana M 

PROVIDER: S-EPMC10585112 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature