Decision making in clinical trials: Interim analyses, innovative design, and biomarkers.

ABSTRACT: The efficient and accurate execution of clinical trials testing novel treatments for Alzheimer's disease (AD) is a critical component of the field's collective efforts to develop effective disease-modifying treatments for AD. The lengthy and heterogeneous nature of clinical progression in AD contributes to the challenges inherent in demonstrating a clinically meaningful benefit of any potential new AD therapy. The failure of many large and expensive clinical trials to date has prompted a focus on optimizing all aspects of decision making, to not only expedite the development of new treatments, but also maximize the value of the information that each clinical trial yields, so that all future clinical trials (including those that are negative) will contribute toward advancing the field. To a

SUBMITTER: Welsh-Bohmer KA 

PROVIDER: S-EPMC10585126 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature