Surgery in rare bleeding disorders: the prospective MARACHI study.

ABSTRACT:

Background

Despite the wide use of bleeding scores and the reliability of clotting factor level measurement, bleeding risk stratification before surgery remains challenging in patients with rare inherited bleeding disorders.

Objectives

This multicenter observational prospective study assessed in patients with rare coagulation factor deficiency, the perioperative hemostatic management choices by hemostasis experts and the bleeding outcomes after surgery.

Methods

One hundred seventy-eight patients with low coagulation activity level (factor [F] II, FV, combined FV-FVIII, FVII, FX, or FXI <50%) underwent 207 surgical procedures. The bleeding outcome, Tosetto's bleeding score, and perioperative hemostatic protocols were collected.

Results

Among the 81 procedures pe

SUBMITTER: Rousseau F 

PROVIDER: S-EPMC10585326 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature