Cochlear-optimized treatment planning in photon and proton radiosurgery for vestibular schwannoma patients.

ABSTRACT:

Objective

To investigate the potential to reduce the cochlear dose with robotic photon radiosurgery or intensity-modulated proton therapy planning for vestibular schwannomas.

Materials and methods

Clinically delivered photon radiosurgery treatment plans were compared to five cochlear-optimized plans: one photon and four proton plans (total of 120). A 1x12 Gy dose was prescribed. Photon plans were generated with Precision (Cyberknife, Accuray) with no PTV margin for set-up errors. Proton plans were generated using an in-house automated multi-criterial planning system with three or nine-beam arrangements, and applying 0 or 3 mm robustness for set-up errors during plan optimization and evaluation (and 3 % range robustness). The sample size was calculated based on a reduction of

SUBMITTER: Koetsier KS 

PROVIDER: S-EPMC10585330 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature