AIM2 promotes T_H17 cells differentiation by regulating RORγt transcription activity.

ABSTRACT: AIM2 is an interferon-inducible HIN-200 protein family member and is well-documented for its roles in innate immune responses as a DNA sensor. Recent studies have highlighted AIM2's function on regulatory T cells (Treg) and follicular T cells (Tfh). However, its involvement in Th17 cell differentiation remains unclear. This study reveals that AIM2 promotes Th17 cell differentiation. AIM2 deficiency decreases IL-17A production and downregulates key Th17 associated proteins (RORγt, IL-1R1, IL-23R). AIM2 is located in the nucleus of Th17 cells, where it interacts with RORγt, enhancing its binding to the Il17a promoter. The absence of AIM2 hinders naive CD4 T cells from differentiating into functional Th17 cells and from inducing colitis in Rag1^-/- mice. This study uncovers AIM2's r

SUBMITTER: Leite JA 

PROVIDER: S-EPMC10585393 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature