Ontology highlight
ABSTRACT:
SUBMITTER: Jia G
PROVIDER: S-EPMC10585397 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Jia Guiquan G Ramalingam Thirumalai R TR Heiden Jason Vander JV Gao Xia X DePianto Daryle D Morshead Katrina B KB Modrusan Zora Z Ramamoorthi Nandhini N Wolters Paul P Lin Celia C Khanna Dinesh D Arron Joseph R JR
iScience 20231005 11
Systemic sclerosis (SSc) interstitial lung disease (ILD) is among the leading causes of SSc-related morbidity and mortality. Tocilizumab (TCZ, anti-IL6RA) has demonstrated a reduced rate of pulmonary function decline in two phase 2/3 trials (faSScinate and focuSSced) in SSc-ILD patients. We performed transcriptome analysis of skin biopsy samples collected in the studies to decipher gene networks that were potentially associated with clinical responses to TCZ treatment. One module correlated with ...[more]