A fingerprint of 2-[¹⁸F]FDG radiometabolites - How tissue-specific metabolism beyond 2-[¹⁸F]FDG-6-P could affect tracer accumulation.

ABSTRACT: Studies indicate that the radiotracer 2-[¹⁸F]fluoro-2-deoxy-D-glucose (2-[¹⁸F]FDG) can be metabolized beyond 2-[¹⁸F]FDG-6-phosphate (2-[¹⁸F]FDG-6-P), but its metabolism is incompletely understood. Most importantly, it remains unclear whether downstream metabolism affects tracer accumulation in vivo. Here we present a fingerprint of 2-[¹⁸F]FDG radiometabolites over time in cancer cells, corresponding tumor xenografts and murine organs. Strikingly, radiometabolites representing glycogen metabolism or the oxPPP correlated inversely with tracer accumulation across all examined tissues. Recent studies suggest that not only hexokinase, but also hexose-6-phosphate dehydrogenase (H6PD), an enzyme of the oxidative pentose phosphate pathw

SUBMITTER: Patronas EM 

PROVIDER: S-EPMC10585399 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature