Targeted magnetic resonance imaging (tMRI) of small changes in the T₁ and spatial properties of normal or near normal appearing white and gray matter in disease of the brain using divided subtracted inversion recovery (dSIR) and divided reverse subtracted inversion recovery (drSIR) sequences.

ABSTRACT: This review describes targeted magnetic resonance imaging (tMRI) of small changes in the T₁ and the spatial properties of normal or near normal appearing white or gray matter in disease of the brain. It employs divided subtracted inversion recovery (dSIR) and divided reverse subtracted inversion recovery (drSIR) sequences to increase the contrast produced by small changes in T₁ by up to 15 times compared to conventional T₁-weighted inversion recovery (IR) sequences such as magnetization prepared-rapid acquisition gradient echo (MP-RAGE). This increase in contrast can be used to reveal disease with only small changes in T₁ in normal appearing white or gray matter that is not apparent on conventional MP-RAGE, T₂-weighted spin echo (T

SUBMITTER: Ma YJ 

PROVIDER: S-EPMC10585510 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature