Janus Kinase Inhibitors and Adverse Events of Acne: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Janus kinase (JAK) inhibitors are increasingly used across a range of dermatologic conditions. Adverse events of acne have been noted in some studies in clinical practice, but the scope of this outcome across JAK inhibitors has not been established.

Objective

To systematically analyze all published phase 2 and 3 placebo-controlled randomized clinical trials (RCTs) of JAK inhibitors for the risk of acne as an adverse effect of these medications.

Data sources

Comprehensive search of Ovid MEDLINE and PubMed databases through January 31, 2023.

Study selection

Inclusion criteria were phase 2 and 3 placebo-controlled RCTs of JAK inhibitors published in English with reported adverse events of acne.

Data extraction and synthesis

Two reviewers independ

SUBMITTER: Martinez J 

PROVIDER: S-EPMC10585588 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature