Prospective Observational Study Evaluating Systemic Hormones and Corneal Crosslinking Effects in Keratoconus.

ABSTRACT:

Purpose

To evaluate associations between hormone levels and corneal parameters in patients with keratoconus (KC), before and after photooxidative corneal collagen crosslinking (CXL).

Design

Prospective, observational cohort study.

Participants

Twenty-eight patients with KC who were scheduled for CXL at Aarhus University Hospital in Denmark.

Methods

Androgen (dehydroepiandrosterone sulfate [DHEA-S]) and estrogen (estrone and estriol) plasma levels were measured and clinical assessments were performed before CXL and 2 to 3 months post-CXL, comparing the CXL eye with the control eye from the same participant.

Main outcome measures

Associations between hormone levels and maximum corneal curvature (K_max) and minimum central corneal thickness (CCt

SUBMITTER: Van L 

PROVIDER: S-EPMC10585634 | biostudies-literature | 2024 Mar-Apr

REPOSITORIES: biostudies-literature