Hybrid and SARS-CoV-2-vaccine immunity in kidney transplant recipients.

ABSTRACT:

Background

Kidney transplant recipients (KTR) are at high risk for severe COVID-19 and have demonstrated poor response to vaccination, making it unclear whether successive vaccinations offer immunity and protection.

Methods

We conducted a serologically guided interventional study where KTR patients that failed to seroconvert were revaccinated and also monitored seroconversion of KTR following the Norwegian vaccination program. We analysed IgG anti-RBD Spike responses from dose 2 (n = 432) up to after the 6th (n = 37) mRNA vaccine dose. The frequency and phenotype of Spike-specific T and B cell responses were assessed in the interventional cohort after 3-4 vaccine doses (n = 30). Additionally, we evaluated the Specific T and B cell response to breakthrough infection (n = 32),

SUBMITTER: Kared H 

PROVIDER: S-EPMC10585642 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature