Persistent dyslipidemia increases the longitudinal changes in telomere length.

ABSTRACT:

Background and aims

Leukocyte telomere length (LTL) as a 'biological clock' of aging is closely related to human health, its association with an aging-related disease, dyslipidemia, has been less studied and mainly focused on cross-sectional investigations.

Methods

Two rounds of information and blood collections were conducted on a cohort of 1624 individuals residing in rural Ningxia, located in northwest China, with an average time gap of 9.8 years. The relative telomere length (RTL) of peripheral blood leukocytes was assessed using real-time quantitative PCR. To investigate the association between dyslipidemia, blood lipid levels, and alterations in RTL, multiple linear regression and generalized linear models were employed.

Results

After conducting the follow-up an

SUBMITTER: Liu X 

PROVIDER: S-EPMC10585729 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature