Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.

ABSTRACT:

Background

Few studies have assessed air pollution exposure association with birthweight during both preconception and gestational periods.

Methods

Leveraging a preconception cohort consisting of 14220 pregnant women and newborn children in Shanghai, China during 2016-2018, we aim to assess associations of NO₂ and PM_2.5 exposure, derived from high-resolution spatial-temporal models, during preconception and gestational periods with outcomes including term birthweight, birthweight Z-score, small-for-gestational age (SGA) and large-for-gestational age (LGA). Linear and logistic regressions were used to estimate 3-month preconception and trimester-averaged air pollution exposure associations; and distributed lag models (DLM) were used to identify critical

SUBMITTER: Liao J 

PROVIDER: S-EPMC10585741 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature