Cellular senescence-related genes: predicting prognosis in hepatocellular carcinoma.

ABSTRACT: Recent studies have shown that the high incidence and low cure rate of hepatocellular carcinoma (HCC) have not improved significantly. Surgery and liver transplantation are the mainstays of prolonging the survival of HCC patients. However, the surgical resection rate of HCC patients is very low, and even after radical surgical resection, the recurrence rate at 5 years postoperatively remains high and the prognosis is very poor, so more treatment options are urgently needed. Increasing evidence suggests that cellular senescence is not only related to cancer development but may also be one of its primary driving factors. We aimed to establish a prognostic signature of senescence-associated genes to predict the prognosis and therapeutic response of HCC patients. The aim of this study was to d

SUBMITTER: Yuan W 

PROVIDER: S-EPMC10585749 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature