Adaptive designs in critical care trials: a simulation study.

ABSTRACT:

Background

Adaptive clinical trials are growing in popularity as they are more flexible, efficient and ethical than traditional fixed designs. However, notwithstanding their increased use in assessing treatments for COVID-19, their use in critical care trials remains limited. A better understanding of the relative benefits of various adaptive designs may increase their use and interpretation.

Methods

Using two large critical care trials (ADRENAL.

Clinicaltrials

gov number, NCT01448109. Updated 12-12-2017; NICE-SUGAR.

Clinicaltrials

gov number, NCT00220987. Updated 01-29-2009), we assessed the performance of three frequentist and two bayesian adaptive approaches. We retrospectively re-analysed the trials with one, two, four, and nine equally spaced interims. Usi

SUBMITTER: Li W 

PROVIDER: S-EPMC10585789 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature