Physiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study.

ABSTRACT:

Background

Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV), physiological data on lung mechanics during MV are lacking. We aimed at describing the physiological effect of lung-protective ventilation in patients with AE-ILD-UIP compared with primary ARDS.

Methods

Partitioned lung and chest wall mechanics were assessed in a series of AE-ILD-UIP patients matched 1:1 with primary ARDS as controls (based on BMI and PaO₂/FiO₂ ratio). Three PEEP levels (zero = ZEEP, 4-8 cmH₂O = PEEP_LOW, and titrated to achieve positive end-expiratory transpulmonary pressure P_L,EE = PEEP_TITRATED) wer

SUBMITTER: Tonelli R 

PROVIDER: S-EPMC10585808 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature