Overall survival following stereotactic radiosurgery for ten or more brain metastases: a systematic review and meta-analysis.

ABSTRACT:

Background

Brain metastases are the most common intracranial tumours. Variation exists in the use of stereotactic radiosurgery for patients with 10 or more brain metastases. Concerns include an increasing number of brain metastases being associated with poor survival, the lack of prospective, randomised data and an increased risk of toxicity.

Methods

We performed a systematic review and meta-analysis to assess overall survival of patients with ten or more brain metastases treated with stereotactic radiosurgery as primary therapy. The search strings were applied to MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL). Log hazard ratios and standard errors were estimated from each included study. A random-effects meta-analysis using the DerSimonian

SUBMITTER: Rozati H 

PROVIDER: S-EPMC10585836 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature