UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer.

ABSTRACT:

Background

Epithelial ovarian cancer (EOC) is a global health burden, with the poorest five-year survival rate of the gynecological malignancies due to diagnosis at advanced stage and high recurrence rate. Recurrence in EOC is driven by the survival of chemoresistant, stem-like tumor-initiating cells (TICs) that are supported by a complex extracellular matrix and immunosuppressive microenvironment. To target TICs to prevent recurrence, we identified genes critical for TIC viability from a whole genome siRNA screen. A top hit was the cancer-associated, proteoglycan subunit synthesis enzyme UDP-glucose dehydrogenase (UGDH).

Methods

Immunohistochemistry was used to characterize UGDH expression in histological and molecular subtypes of EOC. EOC cell lines were subtyped according

SUBMITTER: Harrington BS 

PROVIDER: S-EPMC10585874 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature