Denosumab administration for bone metastases from solid tumors: a retrospective cross-sectional study.

ABSTRACT:

Background

Little is known on how denosumab reduces skeletal-related events (SREs) by bone metastases from solid tumors. We sought to evaluate the effect of denosumab administration in patients with bone metastases from solid tumors.

Methods

Data of patients treated with denosumab were collected from electronic medical charts (n = 496). Eligible participants in this study were adult patients (age ≥ 18 years) with metastatic bone lesions from solid tumors treated with denosumab. SREs, surgical interventions, the spinal instability neoplastic score (SINS) for spinal region, and Mirels' score for the appendicular region were evaluated. To assess whether denosumab could prevent SREs and associated surgery, the SINS and Mirels' score were compared between patients with and withou

SUBMITTER: Mizuta K 

PROVIDER: S-EPMC10585877 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature