Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma.

ABSTRACT:

Background

Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresistance. Nevertheless, the role of RPA in autophagy is not adequately understood. This investigation was performed to reveal the cytotoxic mechanism of a pharmacologic RPA inhibitor (RPAi) in NPC cells and the underlying mechanism by which RPAi-mediated autophagy regulates NPC radiosensitivity.

Methods and results

We characterized a potent RPAi (HAMNO) that was substantially correlated with radiosensitivity enhancement and proliferative inhibition of in vivo and in NPC cell lines in vitro. We show that the RPAi induced autophagy at multiple levels by inducing aut

SUBMITTER: Feng Y 

PROVIDER: S-EPMC10585929 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature