PD-L1 expression-related PI3K pathway correlates with immunotherapy efficacy in gastric cancer.

ABSTRACT:

Background

The programed death ligand-1 combined positive score (PD-L1 CPS), the only FDA-approved biomarker for immune checkpoint inhibitor therapy in gastric cancer (GC) patients, is an important but imperfect predictive biomarker. The molecular characteristics of tumors that influence the PD-L1 CPS are largely unknown and would be helpful for screening patients who would benefit from immunotherapy.

Methods

PD-L1 immunohistochemistry (IHC) and targeted next-generation sequencing techniques were used to compare genomic alterations in 492 GC patients in two groups (PD-L1 CPS ⩾ 1, positive; CPS < 1, negative). Screened PD-L1 expression-related factors were analyzed for immunotherapy efficacy in three distinct GC cohorts from public databases.

Results

Positive PD-L1 exp

SUBMITTER: Liu L 

PROVIDER: S-EPMC10586003 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature