Canagliflozin alters the gut, oral, and ocular surface microbiota of patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Modifications in the gut microbiota may be a crucial factor in the efficacy of canagliflozin (Cana) in managing patients with type 2 diabetes mellitus (T2DM). However, the interplay between oral and ocular surface microbiota and this treatment remains poorly explored.

Aim

This study aimed to assess alterations in the gut, oral, and ocular surface microbiota pre- and post-Cana treatment in patients with T2DM.

Methods

In this 30-day, controlled before-and-after study, 21 treatment-naïve patients with T2DM received sole treatment with Cana (100 mg/day), and were matched with 10 healthy controls based on gender and age. Using 16S rRNA sequencing, changes in the gut, oral, and ocular surface microbiota pre- and post-Cana treatment were assessed and compared with

SUBMITTER: Wang L 

PROVIDER: S-EPMC10586052 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature