Characterization of Structurally Diverse ¹⁸F-Labeled d-TCO Derivatives as a PET Probe for Bioorthogonal Pretargeted Imaging.

ABSTRACT: Background: The pretargeted imaging strategy using inverse electron demand Diels-Alder (IEDDA) cycloaddition between a trans-cyclooctene (TCO) and tetrazine (Tz) has emerged and rapidly grown as a promising concept to improve radionuclide imaging and therapy in oncology. This strategy has mostly relied on the use of radiolabeled Tz together with TCO-modified targeting vectors leading to a rapid growth of the number of available radiolabeled tetrazines, while only a few radiolabeled TCOs are currently reported. Here, we aim to develop novel and structurally diverse ¹⁸F-labeled cis-dioxolane-fused TCO (d-TCO) derivatives to further expand the bioorthogonal toolbox for in vivo ligation and evaluate their potential for positron emission tomography (PET) p

SUBMITTER: Adhikari K 

PROVIDER: S-EPMC10586181 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature