Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases.

ABSTRACT:

Objective

The pathogenesis of peptic ulcer diseases (PUDs) involves multiple factors, and the contribution of gut microbiota to this process remains unclear. While previous studies have associated gut microbiota with peptic ulcers, the precise nature of the relationship, whether causal or influenced by biases, requires further elucidation.

Design

The largest meta-analysis of genome-wide association studies was conducted by the MiBioGen consortium, which provided the summary statistics of gut microbiota for implementation in the Mendelian randomization (MR) analysis. Summary statistics for five types of PUDs were compiled using the FinnGen Consortium R8 release data. Various statistical techniques, including inverse variance weighting (IVW), MR-Egger, weighted median (WM), we

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10586326 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature