Nebulization of Model Hydrogel Nanoparticles to Macrophages at the Air-Liquid Interface.

ABSTRACT: Nanoparticle evaluation within the pulmonary airspace has increasingly important implications for human health, with growing interest from drug delivery, environmental, and toxicology fields. While there have been widespread investigations of nanoparticle physiochemical properties following many routes of administration, nanoparticle behavior at the air-liquid interface (ALI) is less well-characterized. In this work, we fabricate two formulations of poly(ethylene)-glycol diacrylate (PEGDA)-based model nanoparticles to establish an in vitro workflow allowing evaluation of nanoparticle charge effects at the ALI. Both cationic and anionic PEGDA formulations were synthesized with similar hydrodynamic diameters around ~225 nm and low polydispersity, with expected surface charges correspo

SUBMITTER: Sudduth ER 

PROVIDER: S-EPMC10586456 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature