Genetically inducing renal lymphangiogenesis attenuates hypertension in mice.

ABSTRACT:

Background

Hypertension (HTN) is associated with renal proinflammatory immune cell infiltration and increased sodium retention. We reported previously that renal lymphatic vessels, which are responsible for trafficking immune cells from the interstitial space to draining lymph nodes, increase in density under hypertensive conditions. We also demonstrated that augmenting renal lymphatic density can prevent HTN in mice. Whether renal lymphangiogenesis can treat HTN in mice is unknown. We hypothesized that genetically inducing renal lymphangiogenesis after the establishment of HTN would attenuate HTN in male and female mice from three different HTN models.

Methods

Mice with inducible kidney-specific overexpression of VEGF-D (KidVD) experience renal lymphangiogenesis upon doxycy

SUBMITTER: Goodlett BL 

PROVIDER: S-EPMC10586591 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature