Genetic modulation of CWD prion propagation in cervid PrP Drosophila.

ABSTRACT: Chronic wasting disease is a fatal prion condition of cervids such as deer, elk, moose and reindeer. Secretion and excretion of prion infectivity from North American cervids with this condition causes environmental contamination and subsequent efficient lateral transmission in free-ranging and farmed cervids. Variants of cervid PrP exist that affect host susceptibility to chronic wasting disease. Cervid breeding programmes aimed at increasing the frequency of PrP variants associated with resistance to chronic wasting disease may reduce the burden of this condition in animals and lower the risk of zoonotic disease. This strategy requires a relatively rapid and economically viable model system to characterise and support selection of prion disease-modifying cervid PrP variants. Here, we gene

SUBMITTER: Thackray AM 

PROVIDER: S-EPMC10586768 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature