Prognostic significance of limited resection in pathologic stage I lung adenocarcinoma with spread through air spaces.

ABSTRACT:

Background

Tumor spread through air spaces (STAS) is now recognized as tumor invasion. However, the association between STAS and procedure-specific outcomes (limited resection and lobectomy) in patients with pathologic stage I lung adenocarcinoma (ADC) is still under investigation.

Methods

To investigate whether limited resection predicts poorer survival in such patients, we retrospectively analyzed the clinicopathologic features of a large cohort of 1,566 patients with stage I ADC from 2017 to 2020 and classified them according to STAS status and surgical method. Kaplan-Meier, Cox hazard proportional regression, and propensity score matching (PSM) were adopted for prognostic evaluation.

Results

STAS-positive patients had worse recurrence-free survival (RFS) (P<0.001).

SUBMITTER: Xu K 

PROVIDER: S-EPMC10586949 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature