TrisOxine abiotic siderophores for technetium complexation: radiolabeling and biodistribution studies.

ABSTRACT:

Background

Despite the development of positron emission tomography (PET), single photon emission computed tomography (SPECT) still accounts for around 80% of all examinations performed in nuclear medicine departments. The search for new radiotracers or chelating agents for Technetium-99m is therefore still ongoing. O-TRENSOX and O-TRENOX two synthetic siderophores would be good candidates for this purpose as they are hexadentate ligands based on the very versatile and efficient 8-hydroxyquinoline chelating subunit. First, the radiolabeling of O-TRENOX and O-TRENSOX with ^99mTc was investigated. Different parameters such as the quantity of chelating agent, type of reducing agent, pH and temperature of the reaction mixture were adjusted in order to find the best radiolabeli

SUBMITTER: Leenhardt J 

PROVIDER: S-EPMC10587049 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature