Adrenergic modulation of melanocortin pathway by hunger signals.

ABSTRACT: Norepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system is targeted by several anti-obesity drugs. To better understand the circuitry underlying adrenergic appetite control, here we investigated the paraventricular hypothalamic nucleus (PVN), a key brain region that integrates energy signals and receives dense nor/adrenergic input, using a mouse model. We found that PVN NE level increases with signals of energy deficit and decreases with food access. This pattern is recapitulated by the innervating catecholaminergic axon terminals originating from NTS^TH-neurons. Optogenetic activation of rostral-NTS^TH → PVN projection elicited strong motivation to eat comparable to overnight fasting whereas its inhibition attenuated both fasting-induced &

SUBMITTER: Sayar-Atasoy N 

PROVIDER: S-EPMC10587058 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature