Ontology highlight
ABSTRACT:
SUBMITTER: Lin Z
PROVIDER: S-EPMC10587083 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Lin Zhibin Z Yang Peijun P Hu Yufeng Y Xu Hao H Duan Juanli J He Fei F Dou Kefeng K Wang Lin L
Nature communications 20231020 1
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Recent studies show that innate immunity-related signaling pathways fuel NAFLD progression. This study aims to identify potent regulators of innate immunity during NAFLD progression. To this end, a phenotype-based high-content screening is performed, and RING finger protein 13 (RNF13) is identified as an effective inhibitor of lipid accumulation in vitro. In vivo gain- and loss-of-function assays are conducted ...[more]