Selective inhibition of the amyloid matrix of Escherichia coli biofilms by a bifunctional microbial metabolite.

ABSTRACT: The propensity of bacteria to grow collectively in communities known as biofilms and their ability to overcome clinical treatments in this condition has become a major medical problem, emphasizing the need for anti-biofilm strategies. Antagonistic microbial interactions have extensively served as searching platforms for antibiotics, but their potential as sources for anti-biofilm compounds has barely been exploited. By screening for microorganisms that in agar-set pairwise interactions could antagonize Escherichia coli's ability to form macrocolony biofilms, we found that the soil bacterium Bacillus subtilis strongly inhibits the synthesis of amyloid fibers -known as curli-, which are the primary extracellular matrix (ECM) components of E. coli biofilms. We identified bacillaene, a B. subt

SUBMITTER: Cordisco E 

PROVIDER: S-EPMC10587114 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature