Acamprosate reduces ethanol intake in the rat by a combined action of different drug components.

ABSTRACT: Alcohol misuse accounts for a sizeable proportion of the global burden of disease, and Campral^® (acamprosate; calcium-bis-(N-acetylhomotaurinate)) is widely used as relapse prevention therapy. The mechanism underlying its effect has in some studies been attributed to the calcium moiety and not to the N-acetylhomotaurine part of the compound. We recently suggested that the dopamine elevating effect of acamprosate is mediated both by N-acetylhomotaurine and calcium in a glycine receptor dependent manner. Here we aimed to explore, by means of in vivo microdialysis, if our previous study using local administration was functionally relevant and if systemic administration of the sodium salt of N-acetylhomotaurine (sodium acamprosate; 200 mg/kg, i.p.) enhanced the effects of calcium ch

SUBMITTER: Ademar K 

PROVIDER: S-EPMC10587117 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature