General, open-source vertex modeling in biological applications using Tissue Forge.

ABSTRACT: Vertex models are a widespread approach for describing the biophysics and behaviors of multicellular systems, especially of epithelial tissues. Vertex models describe a wide variety of developmental scenarios and behaviors like cell rearrangement and tissue folding. Often, these models are implemented as single-use or closed-source software, which inhibits reproducibility and decreases accessibility for researchers with limited proficiency in software development and numerical methods. We developed a physics-based vertex model methodology in Tissue Forge, an open-source, particle-based modeling and simulation environment. Our methodology describes the properties and processes of vertex model objects on the basis of vertices, which allows integration of vertex modeling with the particle-bas

SUBMITTER: Sego TJ 

PROVIDER: S-EPMC10587242 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature